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Cis-interaction between CD52 and T cell receptor complex interferes with CD4+ T cell activation in acute decompensation of cirrhosis

13 Sept 2024

Abstract excerpt

Background Immune dysfunction contributes to a high rate of infection in patients with acute decompensation of cirrhosis. CD52 is a glycoprotein prominently expressed in lymphocytes. Immune regulation by CD52 may be involved in adaptive immune dysfunction in cirrhosis. This study aimed to investigate the function of CD52 on CD4 + T cells on the blood of patients with acute decompensation of cirrhosis. Methods The...

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PMID: 39276679
DOI: 10.1016/j.ebiom.2024.105336

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