Article
Expanded antigen-experienced CD160+CD8+effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia.
Journal for immunotherapy of cancer - 1 Apr 2021
Bozorgmehr Najmeh, Okoye Isobel, Oyegbami Olaide, Xu Lai, Fontaine Amelie, Cox-Kennett Nanette, Larratt Loree M, Hnatiuk Mark, Fagarasanu Andrei, Brandwein Joseph, Peters Anthea C, Elahi Shokrollah
Abstract excerpt
BACKGROUND: T cell exhaustion compromises antitumor immunity, and a sustained elevation of co-inhibitory receptors is a hallmark of T cell exhaustion in solid tumors. Similarly, upregulation of co-inhibitory receptors has been reported in T cells in hematological cancers such as chronic lymphocytic leukemia (CLL). However, the role of CD160, a glycosylphosphatidylinositol-anchored protein, as one of these...
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