Article

A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin

2018-12-28

Abstract excerpt

<h4>Background: </h4> Mannheimia haemolytica is the major bacterial infectious agent of bovine respiratory disease complex and causes severe morbidity and mortality during lung infections. M. haemolytica secretes a protein leukotoxin (Lkt) that binds to the CD18 receptor on leukocytes, initiates lysis, induces inflammation, and causes acute fibrinous bronchopneumonia. Lkt binds the 22-amino acid CD18 signal pepti...

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Literature Corpus work: 3cd27154-f80e-5bd8-b0e9-601d9f603807
DOI: 10.12688/f1000research.17187.1

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