Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prior exposure to Mannheimia haemolytica leukotoxin or LPS enhances beta(2)-integrin expression by bovine neutrophils and augments LKT cytotoxicity.

Microbial pathogenesis - 1 Jun 2003

Leite F, Gyles S, Atapattu D, Maheswaran S K, Czuprynski C J

Abstract excerpt

Mannheimia (Pasteurella) haemolytica serotype1 produces a variety of virulence factors that play an important role during the pathogenesis of bovine pneumonic pasteurellosis. Among these, a leukotoxin (LKT) and lipopolysaccharide (LPS) are thought to be the primary virulence factors that contribute to the characteristic pathology of pasteurellosis. Recent evidence suggests that M. haemolytica LKT binding to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Bacterial Toxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD18 Antigens

Share to Cytotoxins

Share to Exotoxins

Share to Lipopolysaccharides

Share to Lymphocyte Function-Associated Antigen-1

Share to Neutrophils

Source

Identifiers

PMID: 12782479
DOI: 10.1016/s0882-4010(03)00060-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prior exposure to Mannheimia haemolytica leukotoxin or LPS enhances beta(2)-integrin expression by bovine neutrophils and augments LKT cytotoxicity.PMID 12782479Read ↗

Pasteurella haemolytica leukotoxin induces bovine leukocytes to undergo morphologic changes consistent with apoptosis in vitro.Semantic proximity Read ↗

A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxinSemantic proximity Read ↗

Cytotoxic activity of Mannheimia haemolytica strains in relation to diversity of the leukotoxin structural gene lktA.Semantic proximity Read ↗

BHV-1 infection and inflammatory cytokines amplify the interaction of Mannheimia haemolytica leukotoxin with bovine peripheral blood mononuclear cells in vitroSemantic proximity Read ↗

Passage of CD18- and CD18+ bovine neutrophils into pulmonary alveoli during acute Pasteurella haemolytica pneumonia.Semantic proximity Read ↗

Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.Semantic proximity Read ↗

Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T LymphocytesSemantic proximity Read ↗

High- and low-virulent bovine Pasteurella multocida induced differential NLRP3 inflammasome activation and subsequent IL-1β secretionSemantic proximity Read ↗

Identification of<i>Mannheimia haemolytica</i>Adhesins Involved in Binding to Bovine Bronchial Epithelial CellsSemantic proximity Read ↗

Human CD18 Is the Functional Receptor for<i>Aggregatibacter actinomycetemcomitans</i>LeukotoxinSemantic proximity Read ↗

Bovine leukocyte adhesion deficiency in Holstein cattle.Semantic proximity Read ↗

Feline leukocyte adhesion ( CD 18) deficiency caused by a deletion in the integrin β2( ITGB 2) geneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.