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Human CD18 Is the Functional Receptor for<i>Aggregatibacter actinomycetemcomitans</i>Leukotoxin

17 Jul 2007

Abstract excerpt

Aggregatibacter (Actinobacillus) actinomycetemcomitans is the causative organism of localized aggressive periodontitis, a rapidly progressing degenerative disease of the gingival and periodontal ligaments, and is also implicated in causing subacute infective endocarditis in humans. The bacterium produces a variety of virulence factors, including an exotoxic leukotoxin (LtxA) that is a member of the...

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PMID: 17635865
DOI: 10.1128/iai.00314-07

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