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Article

Cytotoxic activity of Mannheimia haemolytica strains in relation to diversity of the leukotoxin structural gene lktA.

Veterinary microbiology - 2 Apr 2003

Davies Robert L, Baillie Susan

Abstract excerpt

The leukotoxin of Mannheimia haemolytica has a very high degree of amino acid diversity because the lktA gene has a complex mosaic structure that has been derived by horizontal DNA transfer and intragenic recombination. The objective of the present study was to determine the effect of this amino acid diversity on leukotoxin cytotoxicity against bovine and ovine cell types. This was done by comparing the...

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PMID: 12523988
DOI: 10.1016/s0378-1135(02)00408-x

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Cytotoxic activity of Mannheimia haemolytica strains in relation to diversity of the leukotoxin structural gene lktA.PMID 12523988Read ↗

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