Article

Inhibition of Acid Sphingomyelinase Blocks Infection with SARS-CoV-2

2020-07-10

Abstract excerpt

We have previously shown that the acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram or maprotiline or genetic down-regulation of the enzyme prevents infection with authentic SARS-CoV-2 or pseudoviral particles expressing pp-VSV-SARS-CoV-2 spike that...

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Literature Corpus work: 3ca83a5a-c402-5321-8d13-4f870e7168d7
DOI: 10.2139/ssrn.3646562

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