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Article

Host sphingomyelin increases West Nile virus infection in vivo

14 Jan 2016

Abstract excerpt

Flaviviruses, such as the dengue virus and the West Nile virus (WNV), are arthropod-borne viruses that represent a global health problem. The flavivirus lifecycle is intimately connected to cellular lipids. Among the lipids co-opted by flaviviruses, we have focused on SM, an important component of cellular membranes particularly enriched in the nervous system. After infection with the neurotropic WNV, mice...

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PMID: 26764042
DOI: 10.1194/jlr.m064212

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