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Article

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

3 May 2023

Abstract excerpt

The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for cholesterol metabolism in the SARS-CoV-2 life cycle and in T cell function. Here we show that blockade of the enzyme Acyl-CoA:cholesterol acyltransferase (ACAT) with...

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PMID: 37134108
DOI: 10.1371/journal.ppat.1011323

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