Article
Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens
2020-04-14
Abstract excerpt
<h4>ABSTRACT</h4> Chloroquine is an anti-malarial and immunosuppressant drug that has cationic amphipathic chemical properties. We performed genome-wide screens in human cells with chloroquine and several other widely used cationic amphipathic drugs (CADs) including the anti-depressants, sertraline (Zoloft) and fluoxetine (Prozac), the analgesic nortriptyline (Pamelor), the anti-arrhythmic amiodarone (Cordarone),...
Topics
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- Bacillus and Francisella bacterial research
- Bacteriophages and microbial interactions
- Infectious Encephalopathies and Encephalitis
- Lipid Membrane Structure and Behavior
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
Identifiers and source
- Literature Corpus work
- c88253ea-f253-5c34-b402-832b1dfb24ae
- DOI
- 10.1101/2020.04.10.035683