Article

Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.

2020-03-17

Abstract excerpt

<title>Abstract</title> <p>Background Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mutually exclusive. The DLG2 gene resides in the 11q-deleted region, thus makes it an interesting NB candidate tumor suppressor gene. Methods We evaluated the associati...

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Literature Corpus work: 3c804e20-cb83-5675-890a-284658bca39c
DOI: 10.21203/rs.2.20811/v2

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