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PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis

24 Feb 2022

Abstract excerpt

PCLAF (PCNA clamp-associated factor), also known as PAF15/ KIAA0101, is overexpressed in most human cancers and is a predominant regulator of tumor progression. However, its biological function in neuroblastoma remains unclear. PCLAF is extremely overexpressed in neuroblastoma and is associated with poor prognosis. Through the analysis of various data sets, we found that the high expression of PCLAF is positively...

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PMID: 35210406
DOI: 10.1038/s41419-022-04635-w

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