Article
11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma.
Cell reports - 22 Sept 2020
Siaw Joachim Tetteh, Javanmardi Niloufar, Van den Eynden Jimmy, Lind Dan Emil, Fransson Susanne, Martinez-Monleon Angela, Djos Anna, Sjöberg Rose-Marie, Östensson Malin, Carén Helena, Trøen Gunhild, Beiske Klaus, Berbegall Ana P, Noguera Rosa, Lai Wei-Yun, Kogner Per, Palmer Ruth H, Hallberg Bengt, Martinsson Tommy
Abstract excerpt
High-risk neuroblastomas typically display an undifferentiated or poorly differentiated morphology. It is therefore vital to understand molecular mechanisms that block the differentiation process. We identify an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in...
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