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MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

11 Sept 2014

Abstract excerpt

MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma cell lines and is required for neuroblastoma cell survival and proliferation. Depletion of MEIS2 in neuroblastoma cells leads to M-phase arrest and mitotic...

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PMID: 25210800
DOI: 10.1038/cddis.2014.370

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