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Article

Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of <i>E2F</i> target genes and a poor prognosis

27 Oct 2011

Abstract excerpt

The tightly controlled network of cell cycle genes consists of a core of cyclin dependent kinases (CDKs) that are activated by periodically expressed cyclins. The activity of the cyclin-CDK complexes is regulated by cyclin dependent kinase inhibitors (CDKIs) and multiple signal transduction routes that converge on the cell cycle. Neuroblastoma are pediatric tumors that belong to the group of small round blue cell...

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PMID: 22034077
DOI: 10.1002/gcc.20926

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