Article

Harnessing PROTAC technology to combat stress hormone receptor activation

2023-03-18

Abstract excerpt

Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects. To complement existing tools of small-molecule-based inhibitors, we present a highly potent, novel catalytically-driven GR degrader, KH-103, based on proteolysis-targeting chimera t...

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Literature Corpus work: 3c7a6daa-01fe-54c4-88ce-4696c1e0de46
DOI: 10.1101/2023.03.17.533120

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