Article

Dissociated non-steroidal glucocorticoid receptor modulators: an update on new compounds

2008-03-01

Abstract excerpt

Background: Glucocorticoids are the most potent anti-inflammatory drugs available and allow successful treatment of several chronic inflammatory and autoimmune diseases. The discovery of the molecular mechanisms of the glucocorticoid receptor (GR), and the recognition that activation and repression of gene expression could be addressed separately, opened the possibility of improving safety profiles by identifying...

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Literature Corpus work: ca7b249b-776b-535d-bae5-a817cab1a0f7
DOI: 10.1517/13543776.18.3.339

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