Glucocorticoid receptor mutants: man-made tools for functional research.

doi:10.1016/j.tem.2011.03.009

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Article

Glucocorticoid receptor mutants: man-made tools for functional research.

Trends in endocrinology and metabolism: TEM - 1 Aug 2011

Beck Ilse M, De Bosscher Karolien, Haegeman Guy

Abstract excerpt

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that can bind to glucocorticoids (GCs). Upon ligand binding, GR sheds its cytoplasmic chaperoning complex and translocates to the nucleus, where it can act as a ligand-dependent transcription factor, transactivating or transrepressing specific gene promoters. Often, GR interacts with specific cofactors to implement a variety of gene...

Topics

Animals
Humans
Mutation
Protein Processing, Post-Translational
Receptors, Glucocorticoid

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Open in PubMed

Identifiers

PMID: 21549614
DOI: 10.1016/j.tem.2011.03.009

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