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Article

Loss of tristetraprolin activates NF-κB induced phenotypic plasticity and primes transition to lethal prostate cancer

2022-08-05

Abstract excerpt

Phenotypic plasticity is a hallmark of cancer and increasingly realized as a mechanism of resistance in androgen indifferent prostate tumors. It is critical to identify mechanisms and actionable targets driving phenotypic plasticity. Here, we report that loss of tristetraprolin (TTP, gene ZFP36 ), an RNA binding protein that regulates mRNA stability increases NF-κB activation and is associated with higher rates o...

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Literature Corpus work
3c5540a8-3601-56d6-924f-6d8db966cbc5
DOI
10.1101/2022.08.05.500896
Open publication

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Loss of tristetraprolin activates NF-κB induced phenotypic plasticity and primes transition to lethal prostate cancerDOI 10.1101/2022.08.05.500896
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