Article

EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer

2025-08-21

Abstract excerpt

<title>Abstract</title> <p>Phenotypic plasticity is a recognized mechanism of therapeutic resistance in prostate cancer (PCa), however current knowledge of driver mechanisms and therapeutic interventions are limited. Using genetically engineered mouse models (GEMMs) devoid of Pten and Rb1, we previously demonstrated the chromatin reprogramming factor enhancer of zeste homolog 2 (EZH2) as an important regulator of...

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Literature Corpus work: 7fd2caa7-a01c-541f-a7d2-433c4b7e621d
DOI: 10.21203/rs.3.rs-7360528/v1

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