Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF.

Genes & development - 1 Dec 2012

Pogenberg Vivian, Ogmundsdóttir Margrét H, Bergsteinsdóttir Kristín, Schepsky Alexander, Phung Bengt, Deineko Viktor, Milewski Morlin, Steingrímsson Eiríkur, Wilmanns Matthias

Abstract excerpt

Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development and an important oncogene in melanoma. MITF heterodimeric assembly with related basic helix-loop-helix leucine zipper transcription factors is highly restricted, and its binding profile to cognate DNA sequences is distinct. Here, we determined the crystal structure of MITF in its apo conformation and in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine Zippers

Share to Microphthalmia-Associated Transcription Factor

Share to Models, Molecular

Share to Protein Structure, Tertiary

Share to Sequence Alignment

Share to Waardenburg Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 23207919
DOI: 10.1101/gad.198192.112
PMCID: PMC3521630

Genes

MITF
MAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF.PMID 23207919Read ↗

Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screenSemantic proximity Read ↗

Novel mechanisms of MITF regulation identified in a mouse suppressor screen.Semantic proximity Read ↗

MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function.Semantic proximity Read ↗

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.Semantic proximity Read ↗

Melanocytes and the microphthalmia transcription factor network.Semantic proximity Read ↗

MITF: master regulator of melanocyte development and melanoma oncogene.Semantic proximity Read ↗

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read ↗

The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.Semantic proximity Read ↗

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Semantic proximity Read ↗

MITF, the Janus transcription factor of melanoma.Semantic proximity Read ↗

Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A.Semantic proximity Read ↗

MITF has a central role in regulating starvation-induced autophagy in melanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.