Article
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.
Nature - 19 Oct 2011
Bertolotto Corine, Lesueur Fabienne, Giuliano Sandy, Strub Thomas, de Lichy Mahaut, Bille Karine, Dessen Philippe, d'Hayer Benoit, Mohamdi Hamida, Remenieras Audrey, Maubec Eve, de la Fouchardière Arnaud, Molinié Vincent, Vabres Pierre, Dalle Stéphane, Poulalhon Nicolas, Martin-Denavit Tanguy, Thomas Luc, Andry-Benzaquen Pascale, Dupin Nicolas, Boitier Françoise, Rossi Annick, Perrot Jean-Luc, Labeille Bruno, Robert Caroline, Escudier Bernard, Caron Olivier, Brugières Laurence, Saule Simon, Gardie Betty, Gad Sophie, Richard Stéphane, Couturier Jérôme, Teh Bin Tean, Ghiorzo Paola, Pastorino Lorenza, Puig Susana, Badenas Celia, Olsson Hakan, Ingvar Christian, Rouleau Etienne, Lidereau Rosette, Bahadoran Philippe, Vielh Philippe, Corda Eve, Blanché Hélène, Zelenika Diana, Galan Pilar, Aubin François, Bachollet Bertrand, Becuwe Céline, Berthet Pascaline, Bignon Yves Jean, Bonadona Valérie, Bonafe Jean-Louis, Bonnet-Dupeyron Marie-Noëlle, Cambazard Fréderic, Chevrant-Breton Jacqueline, Coupier Isabelle, Dalac Sophie, Demange Liliane, d'Incan Michel, Dugast Catherine, Faivre Laurence, Vincent-Fétita Lynda, Gauthier-Villars Marion, Gilbert Brigitte, Grange Florent, Grob Jean-Jacques, Humbert Philippe, Janin Nicolas, Joly Pascal, Kerob Delphine, Lasset Christine, Leroux Dominique, Levang Julien, Limacher Jean-Marc, Livideanu Cristina, Longy Michel, Lortholary Alain, Stoppa-Lyonnet Dominique, Mansard Sandrine, Mansuy Ludovic, Marrou Karine, Matéus Christine, Maugard Christine, Meyer Nicolas, Nogues Catherine, Souteyrand Pierre, Venat-Bouvet Laurence, Zattara Hélène, Chaudru Valérie, Lenoir Gilbert M, Lathrop Mark, Davidson Irwin, Avril Marie-Françoise, Demenais Florence, Ballotti Robert, Bressac-de Paillerets Brigitte
Abstract excerpt
So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes; risk factors associated with RCC include smoking, obesity and hypertension. A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition underlying the...