Article
A germline oncogenic MITF mutation and tumor susceptibility.
European journal of cell biology - 1 Jan 2000
Paillerets Brigitte Bressac-de, Lesueur Fabienne, Bertolotto Corine
Abstract excerpt
MITF (Microphthalmia-associated transcription factor) is a lineage specific transcription factor that plays a critical role in melanocyte homeostasis and whose deregulation has been shown to contribute to melanoma disease. A germline mutation in MITF, impairing SUMOylation and predisposing to cutaneous malignant melanoma, was recently identified. Interestingly, an association of the MITF mutation with coexisting...
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