Article

Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo.

2022-09-07

Abstract excerpt

<title>Abstract</title>In this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SNAr chemistry. Modification of phage-displayed libraries SXCX<italic>n</italic>C-phage,<italic>n</italic> = 3–5, where X is any amino acid except for cysteine by decafluoro-diphenylsulfone (<bold>DFS</bold>), yi...

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Literature Corpus work: 3c352c88-c62a-548c-a80c-bc77e95088f9
DOI: 10.21203/rs.3.rs-1999287/v1

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