Article
In vivo selection of synthetic nucleocapsids for tissue targeting.
Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2023
Olshefsky Audrey, Benasutti Halli, Sylvestre Meilyn, Butterfield Gabriel L, Rocklin Gabriel J, Richardson Christian, Hicks Derrick R, Lajoie Marc J, Song Kefan, Leaf Elizabeth, Treichel Catherine, Decarreau Justin, Ke Sharon, Kher Gargi, Carter Lauren, Chamberlain Jeffrey S, Baker David, King Neil P, Pun Suzie H
Abstract excerpt
Controlling the biodistribution of protein- and nanoparticle-based therapeutic formulations remains challenging. In vivo library selection is an effective method for identifying constructs that exhibit desired distribution behavior; library variants can be selected based on their ability to localize to the tissue or compartment of interest despite complex physiological challenges. Here, we describe further...
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