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Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation <i>in-vivo</i>

2022-08-22

Abstract excerpt

In this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine S N Ar chemistry. Modification of phage-displayed libraries SXCX n C-phage, n =3–5, where X is any amino acid except for cysteine by decafluoro-diphenylsulfone ( DFS ), yields genetically-encoded library of octafluoro-diphen-ylsulfone-crosslinked macrocycl...

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Literature Corpus work
3c18c29b-6735-5538-8b1f-b16a7be1e1d8
DOI
10.1101/2022.08.22.504611
Open publication

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Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation <i>in-vivo</i>DOI 10.1101/2022.08.22.504611
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