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Article

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.

Neuron - 6 Apr 2016

Rannals Matthew D, Hamersky Gregory R, Page Stephanie Cerceo, Campbell Morganne N, Briley Aaron, Gallo Ryan A, Phan BaDoi N, Hyde Thomas M, Kleinman Joel E, Shin Joo Heon, Jaffe Andrew E, Weinberger Daniel R, Maher Brady J

Abstract excerpt

Transcription Factor 4 (TCF4) is a clinically pleiotropic gene associated with schizophrenia and Pitt-Hopkins syndrome (PTHS). To gain insight about the neurobiology of TCF4, we created an in vivo model of PTHS by suppressing Tcf4 expression in rat prefrontal neurons immediately prior to neurogenesis. This cell-autonomous genetic insult attenuated neuronal spiking by increasing the afterhyperpolarization. At the...

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Source

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Identifiers

PMID: 26971948
DOI: 10.1016/j.neuron.2016.02.021
PMCID: PMC4824652

Genes

TCF4
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1.PMID 26971948Read ↗

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