Article

GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a <i>C. elegans</i> model of Parkinson’s disease

2021-07-16

Abstract excerpt

<h4>Background</h4> Parkinson’s disease (PD) is a disabling neurodegenerative disorder in which multiple cell types, including dopaminergic and cholinergic neurons, are affected. The mechanisms of neurodegeneration in PD are unknown, limiting the development of therapies directed at disease-relevant molecular targets. C. elegans is a genetically tractable model system that can be used to disentangle disease mech...

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Literature Corpus work: 0613f848-99ac-553e-9f70-403fcd35e9c8
DOI: 10.1101/2021.07.16.452702

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