Article

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences

2023-02-22

Abstract excerpt

Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function in both health and disease. Genetically manipulating astrocytes is an essential tool in understanding and affecting their roles. Adeno-associated viruses (AAVs) enable rapid genetic manipulation; however, astrocyte specificity of AAVs can be limited, with high off-target expression in ne...

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Literature Corpus work: 3bd83dda-796b-5719-90c3-af3ee149407d
DOI: 10.1101/2023.02.21.529451

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