Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno‐Associated Viral Vector rAAV9P1

10 Apr 2022

Abstract excerpt

Astrocytes have crucial functions in the central nervous system (CNS) and are major players in many CNS diseases. Research on astrocyte-centered diseases requires efficient and well-characterized gene transfer vectors. Vectors derived from the Adeno-associated virus serotype 9 (AAV9) target astrocytes in the brains of rodents and nonhuman primates. A recombinant (r) synthetic peptide-displaying AAV9 variant,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to Viral Infections and Immunology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35398994
DOI: 10.1002/advs.202104979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno‐Associated Viral Vector rAAV9P1PMID 35398994Read ↗

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequencesSemantic proximity Read ↗

Circuit-Specific Targeting of Astrocytes for Genetic ControlSemantic proximity Read ↗

Simple and Highly Specific Targeting of Resident Microglia with Adeno-Associated VirusSemantic proximity Read ↗

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humansSemantic proximity Read ↗

Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.Semantic proximity Read ↗

LRP6-Guided Engineering of AAV9 Variants with Enhanced Blood-Brain Barrier Penetration and Reduced Liver Tropism in Non-Human PrimatesSemantic proximity Read ↗

Microglia-specific targeting by novel capsid-modified AAV6 vectorsSemantic proximity Read ↗

AAV11 permits efficient retrograde targeting of projection neuronsSemantic proximity Read ↗

In SARS-CoV-2, astrocytes are in it for the long haulSemantic proximity Read ↗

Development of an AAV Vector System for Highly Specific and Efficient Gene Expression in MicrogliaSemantic proximity Read ↗

Development of Hydrocephalus in Mice Expressing the G<sub>i</sub>-Coupled GPCR Ro1 RASSL Receptor in AstrocytesSemantic proximity Read ↗

Selection of rAAV Vectors that Cross the Human Blood-Brain Barrier and Target the Central Nervous System Using a Transwell ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.