Article

Mice expressing A53T / A30P mutant alpha-synuclein in dopamine neurons do not display behavioral deficits

2023-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein has been implicated in neurodegenerative diseases such as Parkinson’s disease and Dementia with Lewy bodies, with A53T and A30P mutations shown to be disease-causing. It has been reported that transgenic mice with tyrosine hydroxylase promotor-driven expression of A53T / A30P mutant alpha-synuclein in dopamine neurons provide a useful preclinical model of these conditions by virt...

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Literature Corpus work: 3bcac4cc-ad2b-5d6c-8da4-69e0ff619acd
DOI: 10.1101/2023.05.25.542172

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