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Article

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Apr 2006

von Coelln Rainer, Thomas Bobby, Andrabi Shaida A, Lim Kah Leong, Savitt Joseph M, Saffary Roya, Stirling Wanda, Bruno Kristy, Hess Ellen J, Lee Michael K, Dawson Valina L, Dawson Ted M

Abstract excerpt

Mutations in the genes coding for alpha-synuclein and parkin cause autosomal-dominant and autosomal-recessive forms of Parkinson's disease (PD), respectively. Alpha-synuclein is a major component of Lewy bodies, the proteinaceous cytoplasmic inclusions that are the pathological hallmark of idiopathic PD. Lewy bodies appear to be absent in cases of familial PD associated with mutated forms of parkin. Parkin is an...

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PMID: 16597723
DOI: 10.1523/JNEUROSCI.0414-06.2006
PMCID: PMC6674122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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