Article

Microscopy-guided subcellular proteomic discovery by high-speed ultra-content photo-biotinylation

2023-12-27

Abstract excerpt

Microscopy-guided proteomics at an organelle-dimension resolution is desired for revealing unknown protein constituents at specific disease- or functional-associated regions at the molecular-molecular interactions level. Here, we achieve protein spatial purification by introducing a firmware-integrated microscopy platform that triggers in situ subcellular photo-biotinylation of proteins at user-defined regions of...

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Literature Corpus work: 3b74b945-f6d0-54ea-8d1c-8d748a598206
DOI: 10.1101/2023.12.27.573388

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