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Article

The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases.

Molecular biology of the cell - 1 Mar 2009

Greaves Jennifer, Prescott Gerald R, Fukata Yuko, Fukata Masaki, Salaun Christine, Chamberlain Luke H

Abstract excerpt

SNAP25 is synthesized as a soluble protein but must associate with the plasma membrane to function in exocytosis; however, this membrane-targeting pathway is poorly defined. SNAP25 contains a palmitoylated cysteine-rich domain with four cysteines, and we show that coexpression of specific DHHC palmitoyl transferases is sufficient to promote SNAP25 membrane association in HEK293 cells. siRNA-mediated knockdown of...

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Identifiers

PMID: 19158383
DOI: 10.1091/mbc.e08-09-0944
PMCID: PMC2655257

Genes

SNAP25

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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