Article

Combining accurate tumour genome simulation with crowd-sourcing to benchmark somatic structural variant detection

2017-11-25

Abstract excerpt

<h4>Background</h4> The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness and provide unique therapeutic opportunities. Whole-genome sequencing of tumors can allow exhaustive identification of the specific structural variants present in an individual cancer, facilitating both clinical diagnostics and the discovery of...

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Literature Corpus work: 3b4cb25d-3712-58bb-b831-70bdc5896637
DOI: 10.1101/224733

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