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PRIMPOL and POLI Deficiencies Differentially Affect DNA Repair and Post-Irradiation Survival of Non-Small Cell Lung Cancer Cell Lines

2023-11-17

Abstract excerpt

Radiation therapy (RT) is one of the main approaches of cancer therapy, including non-small cell lung cancer (NSCLC). Radiation-induced DNA double-stranded breaks (DSBs), single-stranded DNA breaks (SSBs) and oxidized nucleobases cause replication fork stalling, chromosomal instability or point mutagenesis and can lead to cell death. Translesion DNA synthesis (TLS) is one of the DNA damage tolerance (DDT) pathways...

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Literature Corpus work
3b4a2a9d-a781-5264-9273-2736bff78bdc
DOI
10.20944/preprints202311.1139.v1
Open publication

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PRIMPOL and POLI Deficiencies Differentially Affect DNA Repair and Post-Irradiation Survival of Non-Small Cell Lung Cancer Cell LinesDOI 10.20944/preprints202311.1139.v1
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