Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44+ and CD133+ Non-Small Cell Lung Cancer Cells Exhibit DNA Damage Response Pathways and Dormant Polyploid Giant Cancer Cell Enrichment Relating to Their p53 Status

28 Apr 2022

Abstract excerpt

Cancer stem cells (CSCs) play a critical role in the initiation, progression and therapy relapse of many cancers including non-small cell lung cancer (NSCLC). Here, we aimed to address the question of whether the FACS-sorted CSC-like (CD44 + &CD133 +) vs. non-CSC (CD44−/CD133− isogenic subpopulations of p53wt A549 and p53null H1299 cells differ in terms of DNA-damage signaling and the appearance of “dormant”...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35563313
DOI: 10.3390/ijms23094922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44+ and CD133+ Non-Small Cell Lung Cancer Cells Exhibit DNA Damage Response Pathways and Dormant Polyploid Giant Cancer Cell Enrichment Relating to Their p53 StatusPMID 35563313Read ↗

DNA Damage Repair Pathways in Cancer Stem CellsSemantic proximity Read ↗

Cellular Responses to Platinum-Based Anticancer Drugs and UVC: Role of p53 and Implications for Cancer TherapySemantic proximity Read ↗

Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasisSemantic proximity Read ↗

Persistent <scp>DNA</scp> damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cellsSemantic proximity Read ↗

DNA Damage in Stem Cells.Semantic proximity Read ↗

Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN StatusSemantic proximity Read ↗

Molecular Pathogenesis of Radiation-Induced Cell Toxicity in Stem CellsSemantic proximity Read ↗

Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening modelsSemantic proximity Read ↗

Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An UpdateSemantic proximity Read ↗

Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.Semantic proximity Read ↗

The paradigm of mutant p53-expressing cancer stem cells and drug resistance.Semantic proximity Read ↗

Cancer Genomics: Restorative Senescence, Transition to Unicellularity, DDR Circuits, and the Status Quo AnteSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.