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Article

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

22 May 2015

Abstract excerpt

INTRODUCTION: Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory phenotype, referred to as primed microglia. To determine the gene expression signature of priming, the transcriptomes of microglia in aging, Alzheimer's disease (AD), and amyotrophic lateral...

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PMID: 26001565
DOI: 10.1186/s40478-015-0203-5

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