Article

VPS41 loss triggers iron overload, oxidative stress, and mitochondrial fragmentation linked to ferroptosis

2026-05-17

Abstract excerpt

The tight regulation of iron homeostasis is of great importance for cellular health. An increase in intracellular iron levels results in the formation of free radicals, which damages macromolecules and membranes, eventually resulting in cell death by Ferroptosis. Recently, we showed that patients with mutations in VPS41 display a severe neurodegenerative phenotype with iron deposition in the brain. VPS41 is well k...

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Literature Corpus work: 3b368997-2db3-509c-9b53-6084e7fb23e6
DOI: 10.64898/2026.05.15.725396

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