Article

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism

2025-10-08

Abstract excerpt

X-linked Dystonia-Parkinsonism (XDP) is a progressive, adult-onset neurodegenerative movement disorder that predominantly affects males of Filipino descent 1-3 . The disease is caused by the insertion of a SINE-VNTR-Alu subfamily F (SVA_F) retrotransposon within an intron of the TATA-box binding protein-associated factor 1 ( TAF1 ) gene 4 . A major barrier to understanding the pathophysiology of XDP has been th...

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Literature Corpus work: 069ff6ac-a6fe-5f48-a136-a666a68caffd
DOI: 10.1101/2025.10.07.680990

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