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Article

A Disease-Associated Mutation Impedes PPIA through Allosteric Dynamics Modulation.

Biochemistry - 15 Jul 2025

Hattori Yoshikazu, Kumashiro Munehiro, Kumeta Hiroyuki, Kyo Taisei, Kawagoe Soichiro, Matsusaki Motonori, Saio Tomohide

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron degeneration. Peptidylprolyl cis-trans isomerase A (PPIA) is a molecular chaperone involved in protein folding, and its dysfunction has been linked to ALS pathogenesis, as proline is recognized as a key residue for maintaining proper folding of ALS-related proteins. A recent study identified a K76E...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40587259
DOI: 10.1021/acs.biochem.5c00260
PMCID: PMC12269060

Genes

PPIA

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