Article

Spatial Architecture of B7-H3-Expressing Cell Subpopulations Predicts Patient Prognosis in Lung Cancer Brain Metastases: A Pilot Study

2026-06-09

Abstract excerpt

<h4>Background: </h4> The clinical outcomes of lung cancer brain metastases (LCBMs) are highly variable. Traditional pathology relies on bulk cell densities. These static measures fail to capture the spatial architecture of the tumor immune microenvironment (TIME). B7-H3 (CD276) represents a key immune checkpoint in LCBMs. We investigated whether the spatial orchestration of B7-H3-expressing cell populations predi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ac84475-7772-547d-9a8f-ab9bf54d13be
DOI: 10.20944/preprints202606.0672.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Architecture of B7-H3-Expressing Cell Subpopulations Predicts Patient Prognosis in Lung Cancer Brain Metastases: A Pilot StudyDOI 10.20944/preprints202606.0672.v1Read

Novel Spatial Approaches to Dissect the Lung Cancer Immune MicroenvironmentSemantic proximity Read

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung CancerSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphomaSemantic proximity Read

Prognostic significance of spatial immune profiles in human solid cancersSemantic proximity Read

Integrative spatial analysis reveals tumor heterogeneity and immune colony niche related to clinical outcomes in small cell lung cancerSemantic proximity Read

High-resolution molecular atlas of a lung tumor in 3DSemantic proximity Read

Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient StratificationSemantic proximity Read

Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapySemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphomaSemantic proximity Read

Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphomaSemantic proximity Read

Density and entropy of immune cells within the tumor microenvironment of primary tumors and matched brain metastasesSemantic proximity Read

Identification and characterization of tertiary lymphoid structures in brain metastasesSemantic proximity Read