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Article

Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America.

Cancer genetics and cytogenetics - 15 Oct 2010

Iniesta Maria D, Gorin Michael A, Chien Ling-Chen, Thomas Samantha M, Milliron Kara J, Douglas Julie A, Merajver Sofia D

Abstract excerpt

The CHEK2*1100delC mutation has been reported to confer a twofold increased risk of breast cancer among carriers. The frequency of the mutation varies among populations. The highest frequency has been described in Northern and Eastern European countries; the frequency may be much lower in North A...

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Source

Identifiers

PMID: 20875877
DOI: 10.1016/j.cancergencyto.2010.07.124

Genes

CHEK2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20875877-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America.PMID 20875877Read ↗

Frequency of CHEK2*1100delC in New York breast cancer cases and controls.Semantic proximity Read ↗

CHEK2 c.1100delC allele is rarely identified in Greek breast cancer cases.Semantic proximity Read ↗

Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.Semantic proximity Read ↗

The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.Semantic proximity Read ↗

CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.Semantic proximity Read ↗

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.Semantic proximity Read ↗

CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.Semantic proximity Read ↗

Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patientsSemantic proximity Read ↗

CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.Semantic proximity Read ↗

A multicenter study of cancer incidence in CHEK2 1100delC mutation carriers.Semantic proximity Read ↗

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