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Article

Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells.

Immunology - 1 Nov 2017

Boudousquie Caroline, Bossi Giovanna, Hurst Jacob M, Rygiel Karolina A, Jakobsen Bent K, Hassan Namir J

Abstract excerpt

The success of immune system-based cancer therapies depends on a broad immune response engaging a range of effector cells and mechanisms. Immune mobilizing monoclonal T cell receptors (TCRs) against cancer (ImmTAC™ molecules: fusion proteins consisting of a soluble, affinity enhanced TCR and an anti-CD3 scFv antibody) were previously shown to redirect CD8+ and CD4+ T cells against tumours. Here we present...

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Identifiers

PMID: 28640942
DOI: 10.1111/imm.12779
PMCID: PMC5629433

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