Article
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy.
Frontiers in immunology - 1 Jan 2021
Basu Amrita, Ramamoorthi Ganesan, Albert Gabriella, Gallen Corey, Beyer Amber, Snyder Colin, Koski Gary, Disis Mary L, Czerniecki Brian J, Kodumudi Krithika
Abstract excerpt
Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells in the tumor which are critical for activation of anti-tumor response either directly by themselves or by stimulating cytotoxic T cell activity. However, presence of immunosuppressive pro-tumorigenic TH subsets in the tumor milieu further contributes to the complexity of regulation of TH cell-mediated immune response. In...
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