Article

Targeting Cooperation of Chronic Inflammation with Epigenetic Reprogramming Triggers a Synthetic Lethality in Glioblastoma Multiforme

2022-03-02

Abstract excerpt

<h4>Background: </h4> Without an effective strategy for targeted therapy, glioblastoma multiforme (GBM) is still incurable, with a median survival of only 15 months. Both chronic inflammation and epigenetic reprogramming are hallmarks of cancer. However, the mechanisms and consequences of their cooperation in GBM remain unknown. Methods Western blotting was carried out to detect levels of various histone modifica...

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Literature Corpus work: 3a6b2515-6848-58b6-9c02-1980178308ab
DOI: 10.21203/rs.3.rs-1394307/v1

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