Article

Microglial expression of the Wnt signalling modulator <i>DKK2</i> differs between human Alzheimer’s disease brains and mouse neurodegeneration models

2022-05-05

Abstract excerpt

Wnt signalling is crucial for synapse and cognitive function. Indeed, deficient Wnt signalling is causally related to increased expression of DKK1, an endogenous negative Wnt regulator, and synapse loss, both of which likely contribute to cognitive decline in Alzheimer’s disease (AD). Increasingly, AD research efforts have probed the neuroinflammatory role of microglia, the resident immune cells of the central ne...

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Literature Corpus work: 3a654ff7-dcb4-5085-9aa1-a129334bd9e7
DOI: 10.1101/2022.05.05.490649

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