Article

Development and testing of a polygenic risk score for breast cancer aggressiveness

2022-08-30

Abstract excerpt

Aggressive breast cancers portend a poor prognosis, but current polygenic risk scores (PRSs) for breast cancer do not reliably predict aggressive cancers. Aggressiveness can be effectively recapitulated using tumor gene expression profiling. Thus, we sought to develop a novel PRS for the risk of recurrence score weighted on proliferation (ROR-P), an established prognostic signature. Using 2,363 breast cancers with...

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Literature Corpus work: 3a52e1b1-4f38-5347-b711-64a43923a4d2
DOI: 10.1101/2022.08.26.22278957

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