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Article

Evaluating the prognostic performance of a polygenic risk score for breast cancer risk stratification.

BMC cancer - 20 Dec 2021

Olsen Maria, Fischer Krista, Bossuyt Patrick M, Goetghebeur Els

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) could potentially improve breast cancer screening recommendations. Before a PRS can be considered for implementation, it needs rigorous evaluation, using performance measures that can inform about its future clinical value. OBJECTIVES: To evaluate the prognostic performance of a regression model with a previously developed, prevalence-based PRS and age as predictors for...

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Identifiers

PMID: 34930164
DOI: 10.1186/s12885-021-08937-8
PMCID: PMC8691010

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