Article

A diverse repertoire of anti-defense systems is encoded in the leading region of plasmids

2023-02-16

Abstract excerpt

Plasmids are an important source of antibiotic-resistance genes that mobilize horizontally between bacteria, including many human pathogens. Bacteria express various defense mechanisms, such as CRISPR-Cas, restriction-modification systems, and SOS-response genes, to prevent the invasion of mobile elements. Yet, plasmids efficiently and robustly overcome these defenses during conjugation. Here, we show that the lea...

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Literature Corpus work: 3a4f7dab-2242-5d90-855d-90007d24354e
DOI: 10.1101/2023.02.15.528439

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